The vaccines do not contain living organisms, and so are safe for people with disorders of the immune system. These people may not respond so well to the vaccine. A very small number of people who are at risk of COVID-19 cannot have the vaccine – this includes people who have severe allergies to a component in the vaccine. Women of childbearing age, those who are pregnant, planning a pregnancy or breastfeeding should read the detailed information on www.nhs.uk/covidvaccination.